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Two years after the events of ObsCure, Shannon and Kenny are now enrolled in the nearby Fallcreek University, while Stan is making ends meet as a pizza delivery boy. Stan and Kenny have to take medication to prevent the effects of the plant from infecting their bodies, while Shannon has been able to adapt to the changes.

As the story begins, a new drug created from a strange flower is quickly s... See morepreading its influence over the University's populace. Soon enough, a small group of students along with the Leafmore High survivors have to face a horde of mutants and stop the spread of contagion before the situation becomes critical.